基本信息

 

 

王昌河 教授

Ph.D. 博士生导师

青年长江学者

神经科学研究中心主任

陕西省杰出青年基金获得者

陕西省“百人计划”青年学者

西安交通大学青年拔尖人才(A类)

贝时璋青年生物物理学家奖获得者

教育部自然科学一等奖获得者(第3完成人)

 

 

 

      王昌河,教授,博士生导师,青年长江学者,神经科学研究中心主任,神经生物学学科带头人,陕西省杰出青年基金获得者,陕西省‘百人计划’青年学者,西安交通大学青年拔尖人才,荣获第六届贝时璋青年生物物理学家奖、教育部自然科学一等奖获得者(第三)、北京大学优秀博士后、北大-清华生命科学联合中心优秀博士后等;目前担任中国生物物理学会神经生物物理分会秘书长、中国生物物理学会科普委员会委员中国老年学学会衰老与抗衰老科学委员会委员、CAMPUS Asia Project学术委员会委员、中国神经修复学会精准治疗分会委员、教育部科学进步奖评审专家、科普中国特聘专家、陕西省科技业务综合管理系统评审专家。

联系方式

西安交通大学

生命科学与技术学院

联系电话:029-82668463-409

E-mail: changhewang@xjtu.edu.cn

           changhecool@163.com

通讯地址:陕西省西安市碑林区咸宁西路28号西安交通大学生命科学与技术学院, 西安,710049

站点计数器
科研背景

 2003年于四川大学吴玉章学院原创新班学院)四川大学-华盛顿大学联合创新班获理学学士学位;2006年于四川大学生命学院获动物学硕士学位;2012年于北京大学分子医学研究所获生理学博士学位;2012-2015年于北京大学分子医学研究所、北大-清华生命科学联合中心(周专实验室)从事博士后研究,2016年获北京大学优秀博士后。2015年入选西安交通大学青年拔尖人才计划,2017年入选陕西省百人计划青年学者,2018年获高等学校科学研究优秀成果奖(自然科学奖)一等奖(第三完成人),2019年获陕西省杰出青年基金,2019年获贝时璋青年生物物理学家将,2019年入选教育部青年长江学者,目前担任中国生物物理学会神经生物物理分会秘书长,中国生物物理学会科普委员会委员,中国老年学学会衰老与抗衰老科学委员会委员、CAMPUS Asia Project(亚洲校园计划)学术委员会委员,中国神经修复学会精准治疗分会委员,教育部科学技术奖评审专家,科普中国特聘专家,陕西省细胞生物学会理事

主要研究方向包括:1)神经分泌与囊泡循环的调控机制,2)突触传递与突触可塑性的调控机制,3)分泌相关神经疾病(帕金森病、精神分裂症、成瘾、痛)的病理机制。实验室拥有电生理(膜片钳记录、sniffer patchUV-flash、钙成像)、电化学(微碳纤电极细胞/脑片/in vivo水平的实时记录、微透析-HPLC分析)、生物成像(confocalTIRFtwo photon、电镜等)、光遗传、行为学及分子生化等特色技术手段,在囊泡分泌、内吞及循环的分子调控机制和帕金森病等相关神经疾病的发病机理等方面取得一系列突破性研究进展。在国际权威学术期刊发表研究论文(SCI30篇,累计影响因子~212.3其中,第一/通讯作者论文共计15篇(中科院1TOP期刊9篇),分别发表在Neuron(2017, Nature Reviews Neuroscience亮点评述;F1000Prime特别推荐),Nature Communications2018, Movement Disorders亮点评述),PNAS2019),Nature Communications2014),EMBO Reports(2016,封面文章)Journal of Cell Biology (2016,同刊发表评述文章对本文进行高度评价),Science Signaling (2017,封面文章,Science亮点评述)Diabetologia(2015,Up front特别推荐论文)Neuroscientists(2019)等期刊上,累计影响因子~110.3(平均影响因子~7.35)。受邀在《中国大百科全书》第三版中负责《胞吐》、《胞吞》和《胞饮》三个条目的撰写工作。

 

教育经历

2008-2012    北京大学    分子医学研究所,生理学博士(指导老师: 周专教授、张曦教授)     

2003-2006    四川大学   生命科学学院,动物学硕士(指导老师: 郭聪教授)
2000-2003    四川大学    吴玉章学院(四川大学-华盛顿大学联合创新班),生物科学学士
工作经历

 

2018-             西安交通大学生命科学与技术学院,教授,博士生导师

2016-2017     西安交通大学生命科学与技术学院,研究员,博士生导师

2012-2015    北京大学分子医学研究所/北大-清华生命科学联合中心,博士后(合作导师: 周专教授)
2006-2014    齐齐哈尔大学生命科学与农林学院,助教/讲师/副教授

 

荣誉与获奖

2019    青年长江学者

2019    贝时璋青年生物物理学家奖

2019    陕西省杰出青年基金获得

2018    量子化神经递质囊泡的分泌机理,教育部自然科学一等奖(第三完成人)
2017    陕西省百人计划青年学者
2016    西安交通大学青年拔尖人才
2017    第一届全国大学生生命科学竞赛三等奖指导老师
2016    北京大学优秀博士后
2014    北大-清华生命科学联合中心优秀博士后
2014    生物膜与膜生物工程国家重点实验室学术报告二等奖
2010    北京大学李彦宏奖学金   
2008    北京大学学业奖学金二等奖
2005    四川大学优秀硕士光华一等奖
2004    四川大学优秀硕士二等奖
2003    四川大学优秀本科毕业论文三等奖
2002    四川大学本科跳级资格
2002    '四川大学-华盛顿大学杰出青年'荣誉称号

2001    四川大学台禅祖寺奖助学金

学术任职

分会主任 

2019 -   陕西省脑疾病分子医学专业委员会副主任委员

2018 -   中国生物物理学会神经生物物理分会副主任委员、秘书长

 

学会委员 

2019 -   中国神经修复学会精准治疗分会委员

2017 -   中国老年学与老年医学学会抗衰老分会委员

2017 -   CAMPUS Asia Project学术委员会委员

2017-    中国生物物理学会科普委员会委员

2018 -   科普中国特聘专家

 

学会理事

2018-             陕西省细胞生物学会理事

2012-2017    黑龙江省蛋白质组学会理事

2011-2015    黑龙江省微生物学会理事

 
学会会员
中国生物物理学会会员
中国神经生物学会会员
中国生理学会会员
中国细胞生物学会会员 
近期代表论文

1.      Rong Huang, Yuan Wang, Jie Li, Xiaohan Jiang, Yinglin Li, Bing, Liu, Xi Wu, Xingyu Du, Yuqi Hang, Mu Jin, Feipeng Zhu, Changhe Wang#, Zuying Chai#, Zhuan Zhou#. (2019) Ca2+-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian synpathetic nervous system. Proc Natl Acad Sci U S A, doi/10.1073/pnas.1902444116. (Epub ahead of print, IF: 9.5, #Corresponding authors).

2.      Xuanang Wu, Shaoqin Hu, Xinjiang Kang#, and Changhe Wang#. (2019) Synaptotagmins: beyond presynaptic neurotransmitter release. Neuroscientist. DOI: 10.1177/1073858419844497. (Epub ahead of print, IF: 7.46, # Corresponding authors) .

3.      Mingzhu Huang, Bianbian Wang, Xiaopeng Li, Chongluo Fu#, Changhe Wang#, and Xinjiang Kang#. (2019) ɑ-Synuclein: a multifunctional player in exocytosis, endocytosis, and vesicle recycling. Frontiers in Neuroscience. 13:28. doi: 10.3389/fnins.2019.00028. (IF: 3.88, # Corresponding authors) (Invited review)

4.      Qian Song, Mingzhu Huang, Bianbian Wang, Xinjiang Kang, Wang Changhe#. (2018) Bidirectional regulation of Ca2+ in exo-endocytosis coupling. Science China Life Sciences. 61(12):1583-1585. (IF: 3.09, # Corresponding author) (Invited review)

5.      Changhe Wang *, Xinjiang Kang *, Li Zhou *, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, and Zhuan Zhou. (2018) Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s Disease like pathology. Nature Communications. 9:81. doi:10.1038/s41467-017-02593-y. (IF: 12.35, *Co-first authors).

Highlighted in Movement Disorders (Moghaddam HS and Arabi MH, Synaptotagmin-11 is a novel hotspot in the pathogenesis of parkin-linked Parkinson’s disease: new implications for clinical targeting, 2018, 33(4):582).

6.      Zuying Chai *, Changhe Wang *, Rong Huang*, Yuan Wang*, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, and Zhuan Zhou. (2017) CaV2.2 gates calcium-independent but voltage-dependent secretion in mammalian sensory neurons. Neuron. 96(6):1317-26. (IF: 14.32, *Co-first authors).

Highlighted in Nature Reviews Neuroscience (Natasha Bray, A discrete form of secretion, 2017, 19(1):6. doi: 10.1038/nrn.2017.162).

Recommended by the Faculty of 1000 (F1000Prime recommendations by Ronald W Holz, F1000Prime recommendations by Yang Yang, and F1000Prime recommendations by William Colmers).

7.      Yeshi Wang, Qihui Wu, Meiqin Hu, Bin Liu, Zuying Chai, Rong Huang, Yuan Wang, Zhou Li, Xu Huadong, Changhe Wang#, and Zhuan Zhou#. (2017) Ligand- and voltage-gated Ca2+ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Science Signaling. 10(484), eaal1683. (IF: 7.36, # Corresponding authors) (Front Cover).

Highlighted in Science (Ferrarelli LK, 2017, Kiss-and-run or a full commitment? 356(6344):1243-1245. doi: 10.1126/science.356.6344.1243-p).

8.      Zhenli Xie, Jiangang Long, Jiankang Liu, Zuying Chai#, Xinjiang Kang#, Changhe Wang#. (2017) Molecular mechanisms for the coupling of endocytosis to exocytosis in neurons. Frontiers in Molecular Neuroscience. 10:47. doi:10.3389/fnmol.2017.00047. (IF: 5.2, # Corresponding authors) (Invited review)

9.      Zuying Chai, Yang Chen, Changhe Wang# (2017) β-arrestin-1: bridging GPCRs to active TRP channels. Channels. 11(5):357-9. (IF: 2.54, # Corresponding author) (Invited commentary)

10.  Changhe Wang*, Yeshi Wang*, Meiqin Hu*, Zuying Chai, Qihui Wu, Rong Huang, Weiping Han, Claire Xi Zhang, Zhuan Zhou. (2016) Synaptotagmin 11 inhibits clathrin-mediated and bulk endocytosis. EMBO Reports. 17(1):47-63. (IF: 9.06, *Co-first authors) (Front Cover)

11.  Shujiang Shang, Feipeng Zhu, Bin Liu, Zuying Chai, Qihui Wu, Meiqin Hu, Yuan Wang, Rong Huang, Xiaoyu Zhang, Xi Wu, Lei Sun, Yeshi Wang, Li Wang, Huadong Xu, Sasa Teng, Bing Liu, Lianghong Zheng, Chen Zhang, Fukang Zhang, Xinghua Feng, Desheng Zhu, Changhe Wang#, Tao Liu#, Michael Xi Zhu#, Zhuan Zhou#. (2016) Intracellular TRPA1 Mediates Ca2+ Release from lysosomes in dorsal root ganglion neurons. The Journal of Cell Biology. 215(3):369-381. (IF: 8.72, # Corresponding authors)

Highlighted in Journal of Cell Biology (Mingxue Gu and Haoxing Xu, A painful TR(i)P to lysosomes, 2016, 215(3):309-312).

12.  Haiqiang Dou*, Changhe Wang*, Xi Wu, Lijun Yao, Xiaoyu Zhang, Sasa Teng, Huadong Xu, Bin Liu, Qihui Wu, Quanfeng Zhang, Meiqin Hu, Yeshi Wang, Li Wang, Yi Wu, Shujiang Shang, Xinjiang Kang, Lianghong Zheng, Jin Zhang, Matthieu Raoux, Jochen Lang, Qing Li, Jing Su, Xiao Yu, Liangyi Chen, Zhuan Zhou. (2015) Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 58(2):324-33. (IF: 6.67, *Co-first authors) (被该刊编辑部选为‘Up front’特别推荐论文).

13.  Huadong Xu, Panli Zuo, Shirong Wang, Li Zhou, Xiaoxuan Sun, Meiqin Hu, Bin Liu, Qihui Wu, Haiqiang Dou, Bing Liu, Feipeng Zhu, Sasa Teng, Xiaoyu Zhang, Li Wang, Qing Li, Mu Jin, Xinjiang Kang#, Wei Xiong, Changhe Wang#, Zhuan Zhou#. (2015) Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo. Analyst. 140:3840-3845. (IF: 4.11, # Corresponding authors)

14.  Li Wang, Shujiang Shang, Xinjiang Kang, Sasa Teng, Feipeng Zhu, Bin Liu, Qihui Wu, Mingli Li, Wei Liu, Huadong Xu, Li Zhou, Ruiying Jiao, Haiqiang Dou, Panli Zuo, Xiaoyu Zhang, Lianghong Zheng, Shirong Wang, Changhe Wang# and Zhuan Zhou#. (2014) Modulation of dopamine release in the striatum by physiologically relevant level of nicotine. Nature Communications. 5:3925. DOI: 10.1038/ncomms4925. (IF: 11. 47, # Corresponding authors)

15.  Shujiang Shang*, Changhe Wang*, Bin Liu, Qihui Wu, Quanfeng Zhang, Wei Liu, Lianghong Zheng, Huadong Xu, Xinjiang Kang, Xiaoyu Zhang, Yeshi Wang, Hui Zheng, Shirong Wang, Wei Xiong, Tao Liu, Zhuan Zhou. (2014) Extracellular Ca2+ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin cells. Cell Calcium. 56(3):202-7. (IF: 4.3, *Co-first authors)

16.  Mingli Li, Huadong Xu, Guoqing Chen, Suhua Sun, Qinglong Wang, Bing Liu, Xi Wu, Li Zhou, Zuying Chai, Xiaoxuan Sun, Yang Lu, Muhammad Younus, Lianghong Zheng, Feipeng Zhu, Hongbo Jia, Xiaowei Chen, Changhe Wang and Zhuan Zhou. (2019) Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson’s disease. Brain. doi: 10.1093/brain/awz243. (Epub ahead of print, IF: 11.81).

17.  Quanfeng Zhang, Bin Liu, Qihui Wu, Bing Liu, Yinglin Li, Suhua Sun, Yuan Wang, Xi Wu, Zuying Chai, Xiaohan Jiang, Xiaoyao Liu, Meiqin Hu, Yeshi Wang, Yunting Yang, Li Wang, Xinjiang Kang,1 Yingfei Xiong, Yang Zhou, Xiaoke Chen, Lianghong Zheng, Bo Zhang, Changhe Wang, Feipeng Zhu, and Zhuan Zhou. (2019) Differential co-release of two neurotransmitters from a vesicle fusion pore in mammalian adrenal chromaffin cells. Neuron. 102(1):173-83. (IF: 14.32).

18.  Qihui Wu, Quanfeng Zhang, Bin Liu, Yinglin Li, Xi Wu, Shuting Kuo, Lianghong Zheng, Changhe Wang, Feipeng Zhu and Zhuan Zhou. (2019) Dynamin-1 restrains vesicular release to a sub-quantal mode in mammalian adrenal chromaffin cells. J Neurosci. 39(2):199-211. (IF: 5.97).

19.  Zhuan Zhou, Zuying Chai, Changhe Wang. (2018) From structure to function: unveiling the structure of the Nav channel–toxin complex. Natl Sci Rev. doi: 10.1093/nsr/nwy090 (Epub ahead of print, IF: 13.22).

20.  Yingfei Xiong, Sasa Teng, Lianghong Zheng, Suhua Sun, Jie Li, Ning Guo, Mingli Li, Li Wang, Feipeng Zhu, Changhe Wang, Zhiren Rao, Zhuan Zhou. (2018) Stretch-induced Ca2+ independent ATP release in hippocampal astrocytes. J Physiol. 596: 1931-47. (IF: 4.74)

21.  Chen Hou, Yongyao Wang, Jiankang Liu, Changhe Wang, Jiangang Long. (2017) Neurodegenerative disease related proteins have negative effects on SNARE-mediated membrane fusion in pathological confirmation. Front Mol Neurosci. 10:66. DOI: 10.3389/fnmol.2017.00066. (IF: 5.2)

22.  Linling He, Quanfeng Zhang, Liecheng Wang, Jingxia Dai, Changhe Wang, Lianghong Zheng, Zhuan Zhou. (2015) Muscarinic inhibition of nicotinic transmission in neurons and adrenal chromaffin cells. Philos Trans R Soc Lond B Biol Sci. 370:20140188. DOI: 10.1098/rstb.2014.0188. (IF: 7.06)

23.  Xinjinag Kang, Huadong Xu, Sasa Teng, Xiaoyu Zhang, Zijun Deng, Li Zhou, Panli Zuo, Bing Liu, Bin Liu, Qihui Wu, Li Wang, Meiqin Hu, Haiqiang Dou, Wei Liu, Feipeng Zhu, Qing Li, Shu Guo, Qian Lei, Jing Lv, Yu Mu, Mu Jin, Shirong Wang, Wei Jiang, Kun Liu, Changhe Wang, Weilin Li, Kang Zhang, Zhuan Zhou. (2014) Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proc Natl Acad Sci USA. 111(44):15804-9. (IF: 9.81) (Weekly press tipsheet特别推荐论文)

24.  Li Wang, Xiaoyu Zhang, Huadong Xu, Li Zhou, Ruiying Jiao, Wei Liu, Feipeng Zhu, Xinjiang Kang, Bin Liu, Sasa Teng, Qihui Wu, Mingli Li, Haiqiang Dou, Panli Zuo, Changhe Wang, Shirong Wang and Zhuan Zhou. (2014) Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice. J Physiol. 592:3559-76. (IF: 5.04)

25.  Lina Liu, Feipeng Zhu, Meiying Song, Xinjiang Kang, Shujiang Shang, Xiaoyu Zhang, Huadong Xu, Sasa Teng, Bin Liu, Shuting Kuo, Wei Liu, Mingli Li, Li Zhou, Ruiying Jiao, Changhe Wang, Shirong Wang, Hui Yang, Bo Zhang, Zhuan Zhou, Zhiqing Xu. (2014) Effect of Cocaine on Ion Channels and Glutamatergic EPSCs in Noradrenergic Locus Coeruleus Neurons. J Mol Neurosci. 53(3):345-51. (IF: 2.76)

26.  Shuting Kuo, Qihui Wu, Bin Liu, Zhenli Xie, Xi Wu, Shujiang Shang, Xiaoyu Zhang, Xinjiang Kang, Lina Liu, Feipeng Zhu, Yeshi Wang, Meiqin Hu, Huadong Xu, Li Zhou, Bin Liu, Zuying Chai, Quanfeng Zhang, Wei Liu, Sasa Teng, Changhe Wang, Ning Guo, Haiqiang Dou, Panli Zuo, Lianghong Zheng, Claire Xi Zhang, Desheng Zhu, Li Wang, Shirong Wang, Zhuan Zhou. (2014) Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese university. J Mol Neurosci. 53(3):487-92. (IF: 2.76)

27.  Tao Liu, Shujiang Shang, Bin Liu, Changhe Wang, Yeshi Wang, Wei Xiong, Lianghong Zheng, Claire Xi Zhang, Zhuan Zhou. (2011) Two distinct vesicle pools for depolarization-induced exocytosis in somata of dorsal root ganglion neurons. J Physiol. 589 (14): 3507-15. (IF: 4.72)

28.  Tao Liu, Lei Sun, Yingfei Xiong, Shujiang Shang, Ning Guo, Sasa Teng, Yeshi Wang, Bin Liu, Changhe Wang, Li Wang, Lianghong Zheng, Claire Xi Zhang, Weiping Han, Zhuan Zhou. (2011) Calcium triggers exocytosis from two types of organelles in a single astrocyte. J Neurosci. 31(29): 10593-601. (IF: 7.12)

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