学术成果

历年发表文章

研究领域与成果:
    
       长期从事营养对衰老及衰老相关疾病在分子细胞生物学水平上的调控研究,重点研究自由基生物学与线粒体代谢机制。在氧化应激、线粒体损伤与预防、线粒体营养素理论等方面具有一定的研究基础与经验,承担了科技部973课题,十二五规划课题,基金委重大研究计划和面上项目及与瑞士雀巢公司和帝斯曼公司,美国安利公司,法国梅里埃研究院等多个国际合作课题。在生物学领域的国际学术期刊发表论文200余篇,被引次数约14782余次,H因子65 (ResearchID: A-1610-2011)。申请专利15项(11项已获授权),主编《线粒体医学》一书,由科学出版社2012年8月出版;主持编写《人体线粒体功能障碍与重大疾病研究》丛书(共10卷)成功入选“十三五”国家重点出版规划图书 ,并获得2019年陕西省和2020年国家出版基金资助。连续六年(2014-2019年)入选爱思维尔高被引中国学者榜单(生物化学,遗传学和分子生物学领域)。

 

 

近年发表的学术论文:

 

2019:

 

1.      Proinflammatory macrophages impair skeletal muscle differentiation in obesity through secretion of tumor necrosis factor‐α via sustained activation of p38 mitogen‐activated protein kinase.

      Wang X, Zhao D, Cui Y, Lu S, Gao D, Liu J.

     Journal of cellular physiology, 2019, 234(3): 2566-2580.

 

2.       Transmembrane protein 215 promotes angiogenesis by maintaining endothelial cell survival.

       Liu Y, Zheng Q, He G, Zhang M, Yan X, Yang Z, Zhang P, Wang L, Liu J, Liang L, Han H.

      Journal of Cellular Physiology, 2019, 234(6): 9525-9534.

 

3.       Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats .

      Liu L, He X, Zhao M, Yang S, Wang S, Yu X, Liu J, Zang W.

     Journal of molecular and cellular cardiology, 2019, 128: 26-37.

  

4.    Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt  Pathways.

       Li C, Xiao L, Jia J, Li F, Wang X, Duan Q, Jing H, Yang P, Chen C, Wang Q, Liu J, Shao Y, Wang N, Zheng Y.

      Journal of Investigative Dermatology, 2018.

 

5.     Punicalagin attenuates endothelial dysfunction by activating FoxO1, a pivotal regulating switch of mitochondrial biogenesis.

        Liu X, Cao K, Lv W, Feng Z, Liu J, Gao J, Li H, Zang W, Liu J. 

        Free Radical Biology and Medicine, 2019, 135: 251-260.

 

6.     Surface loops in a single SH2 domain are capable of encoding the spectrum of specificity of the SH2 family.

        Liu H, Huang H, Voss C, Kaneko T, Qin W, Sidhu S, Li S.

        Molecular & Cellular Proteomics, 2019, 18(2): 372-382.

 

7.     Mutation signatures in germline mitochondrial genome provide insights into human mitochondrial evolution and disease

        Gu X, Kang X, Liu J.  

        Human genetics, 2019, 138(6): 613-624.

 

 

2018:

 

1.  ERK-mediated phosphorylation regulates SOX10 sumoylation and targets expression in mutant BRAF melanoma.

Han S, Ren Y, He W, Liu H, Zhi Z, Zhu X, Yang T, Rong Y, Ma B, Purwin TJ, Ouyang Z, Li C, Wang X, Wang X, Yang H, Zheng Y, Aplin AE, Liu J, Shao Y.

 Nat Commun. 2018 Jan 2;9(1):28. doi: 10.1038/s41467-017-02354-x.

 PMID: 29295999


 

 

2. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.

Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K, Long J, Li Z, Shen W, Liu J.

Cell Death Differ. 2018 Feb;25(2):229-240. doi: 10.1038/cdd.2017.144. Epub 2017 Sep 15. 


 

3. APR3 modulates oxidative stress and mitochondrial function in ARPE-19 cells.

Li Y, Zou X, Gao J, Cao K, Feng Z, Liu J.

FASEB J. 2018 May 24:fj201800001RR. doi: 10.1096/fj.201800001RR. [Epub ahead of print]

PMID: 29792731

 

4. A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells.

Ouyang C, Chen L, Rees TW, Chen Y, Liu J, Ji L, Long J, Chao H.

Chem Commun (Camb). 2018 Jun 14;54(49):6268-6271. doi: 10.1039/c8cc02795a.

PMID: 29850704

 

5. C10orf99 contributes to the development of psoriasis by promoting the proliferation of keratinocytes.

Chen C, Wu N, Duan Q, Yang H, Wang X, Yang P, Zhang M, Liu J, Liu Z, Shao Y, Zheng Y.

Sci Rep. 2018 Jun 5;8(1):8590. doi: 10.1038/s41598-018-26996-z.

   PMID: 29872130 Free PMC Article

  

6. Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.

Xu D, Liao C, Zhang B, Tolbert WD, He W, Dai Z, Zhang W, Yuan W, Pazgier M, Liu J, Yu J, Sansonetti PJ, Bevins CL, Shao Y, Lu W.

Immunity. 2018 Jun 19;48(6):1233-1244.e7. doi: 10.1016/j.immuni.2018.04.014. Epub 2018 May 29.

PMID: 29858013

 

7. Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance.

Hou C, Peng Y, Qin C, Fan F, Liu J, Long J.

Free Radic Res. 2018 Apr 23:1-12. doi: 10.1080/10715762.2018.1460749. [Epub ahead of print]

PMID: 29683360

 

8. Mitochondria regulate cardiac contraction through ATP-dependent and independent mechanisms.

Wang K, Xu Y, Sun Q, Long J, Liu J, Ding J.

Free Radic Res. 2018 Apr 3:1-10. doi: 10.1080/10715762.2018.1453137. [Epub ahead of print]

PMID: 29544373

 

 

9. Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway.

Jia J, Li C, Yang J, Wang X, Li R, Luo S, Li Z, Liu J, Liu Z, Zheng Y.

Sci Rep. 2018 Oct 15;8(1):14513.

 

10. A special issue of SFRR Asia: Cross talk between free radicals and mitochondria in health and disease.

Liu J, Toyokuni S, Surh YJ.

Free Radic Res. 2018 Sep 24:1-51. doi: 10.1080/10715762.2018.1528501.

 

11. Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte Proliferation via Phosphoinositide 3-Kinase/Akt Pathways.

Li C, Xiao L, Jia J, Li F, Wang X, Duan Q, Jing H, Yang P, Chen C, Wang Q, Liu J, Shao Y, Wang N, Zheng Y.

J Invest Dermatol. 2018 Sep 25. pii: S0022-202X(18)32327-3. 

12. Modulation of HIF-2α PAS-B domain contributes to physiological responses.

Feng Z, Zou X, Chen Y, Wang H, Duan Y, Bruick RK.

 Proceedings of the National Academy of Sciences, 2018: 201810897.

 

13.  Oxidative damage of mitochondrial respiratory chain in di