基本信息

Education

2006-2010           Model Animal Research Center, Nanjing University, Ph.D

2000-2003           Institute of Hydrobiology, Chinease Academy of Science, Wuhan, China, M.S.

1996-2000            Hebei University, Baoding, China, B.S.

Work

2011-2015          Yale University School of Medicine, Yale Cancer Center, USA, Postdoctoral Associate

2016-now          Hospital of Stomatology, Xi'an Jiaotong University, Research Professor

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研究领域

Research Interest

1) Molecular pathogenesis of Diffuse Large B Cell Lymphoma( DLBCL)

    DLBCL is a cancer of B cells, a type of immune cell that is responsible for producing antibodies.  DLBCL is the most common type of non-Hodgkin lymphoma in adults and is known for its heterogeneity in biology, pathology and clinical response.  I am interested in understanding this heterogeneity at molecular level with the long term goal of a better personalized precision medicine. 

2) Identification and characterization of novel molecules involved in B cell immunity and B cell malignancy.

3) Dysregulation of B cell response  in oral diseases.   

Publications

1.Gu X, Booth CJ, Liu Z and Strout MP. (2016) AID-associated DNA repair pathways regulate malignant transformation in a murine model of BCL6-driven diffuse large B cell lymphoma. Blood, 127(1):102-12.

2. Vuong BQ, Herrick-Reynolds K, Vaidyanathan B, Pucella JN, Ucher AJ, Donghia NM, Gu X, Nicolas L, Nowak U, Rahman N, Strout MP, Mills KD, Stavnezer J, Chaudhuri J. (2013) A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. Nat Immunol. 14(11):1183-9. 

3.Gu X, Shivarov V, Strout MP. (2012) The role of activation-induced cytidine deaminase in lymphomagenesis. Curr Opin Hematol. 19(4):292-8. 

4.Gu X, Xing L, Shi G, Liu Z, Wang X, Qu Z, Wu X, Dong Z, Gao X, Liu G, Yang L, Xu Y. (2012) The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell Death Differ. 19(3) 397-405.

5.Wu X, Liu Z, Shi G, Xing L, Wang X, Gu X, Qu Z, Dong Z, Xiong J, Gao X, Zhang C, Xu Y. (2011) The circadian clockinfluences heart performance. Journal of Biological Rhythms, 26(5)402-11.

6.Wang X, Tang J, Xing L, Shi G, Ruan H, Gu X, Liu Z, Wu X, Gao X, Xu Y. (2010) Interaction of MAGED1 with nuclear receptors affects circadian clock function. The EMBO Journal 29, 1389-1400.

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