INTRODUCTION

Xiaolong Sun

Nationality: Qingdao, China

E-mail: xs2759@xjtu.edu.cn

WORK EXPERIENCE

10. 2018 – Now, Professor (Young Talent A level) in School of Life Sci. Tech., Xi’an Jiaotong Univ., Xi’an, China;

03. 2015 – 09. 2018, Postdoc Research Fellow in Department of Chemistry, Univ. of Texas at Austin, U.S. Collaborator: Eric V. Anslyn and Andrew Ellington;

03. 2012 – 09. 2012, R&D Chemist, Tokyo Chemical Industry, Shanghai, China;  

EDUCATION

09. 2012 – 03. 2015, PhD, Organic Chemistry, Department of Chemistry, Univ. of Bath, UK; Supervisor: Prof. Tony D. James;

09. 2009 – 02. 2012, MSc, Applied Chemistry, School of Pharmacy, East China Univ. Sci. Tech., Shanghai, China; Supervisor: Prof. Xuhong Qian;

09. 2005 – 06. 2009, BSc, Chemistry, Department of Resource and Environment, Shaanxi Univ. Sci. Tech., Xi’an, China.

My research interests include organic synthesis to prepare small molecules fluorescence probes that can be utilized to understand and exploit biological/environmental systems, mainly in the fluorescent detection of reactive oxygen and nitrogen species, carbohydrates, self-propagating cascades for the detection of nerve agents and combination of small molecular fluorescent probe with supporting materials, such as graphene oxide, porous silicon material, hydrogels. We proposed the strategy of selective detection of peroxynitrile over other reactive oxygen species by using boron-nitrogen interaction. Based on the traditional indicator displacement assay (IDA), we reported a new protocol for the selective detection of targets, referring to reaction-based indicator displacement assay (RIA). We also developed new approaches to auto-Inductive cascades for the optical sensing of fluoride/thiol: application in the ultratrace detection of phosphoryl nerve agents. And we explored and summarized the true mechanism by using nitrogen-boron interaction based fluorescent probe in the detection of saccharides. 


1. Auto-inductive cascades for the optical detection of nerve agents.  

·   

(1) Sun X.,† Boulgakov A. A.,† Smith L. N., Metola P., Marcotte E. M.,* Anslyn E. V.* Photography Coupled with Self-Propagating Chemical Cascades: Differentiation and Quantitation of G and V Nerve Agent Mimics via Chromaticity. ACS. Cent. Sci. 2018, 4, 854-861 (IF: 11.228, Co-first author, Highlighted in more than 100 international medias, including The Fox News, The Times, Atlas, etc.));
(2) Sun X., Dahlhauser S. D., Anslyn E. V.* New Auto-Inductive Cascade for the Optical Sensing of Fluoride: Application in the Detection of Phosphoryl Fluoride Nerve Agents. J. Am. Chem. Soc., 2017, 139, 4635-4638 (IF: 14.357);
(3) Sun X., Anslyn E. V.* An Auto-Inductive Cascade for the Optical Sensing of Thiols in Aqueous Condition: Application in the Detection of a VX Nerve Agent Mimic. Angew. Chem. Int. Ed., 2017, 129, 9650-9654 (IF: 12.102);

(4) Sun X., Reuther J. F., Phillips S. T., Anslyn E. V. Coupling Activity-based Detection, Target Amplification, Colorimetric and Fluorometric Signal Amplification, for Quantitative Chemosensing of Fluoride Generated from Nerve Agents. Chem. Eur. J., 2017, 23, 3903-3909 (IF: 5.160)

(5) Sun X., Shabat, D.,* Phillips S. T.,* Anslyn E. V.* Self-propagating amplification reactions for molecular detection and signal amplification: Advantages, pitfalls, and challenges. J. Phys. Org. Chem. 2018, 31, DOI: 10.1002/poc.3827 (IF: 1.38)

      2. Selective detection of reactive oxygen species and cell imaging.

·        

      Sun X., Lacina K., Ramsamy E., Flower S. E., Fossey J. S., Qian X. H., Anslyn E. V., Bull S. and James T. D., Reaction-based Indicator displacement Assay (RIA) for the selective colorimetric and fluorometric detection of peroxynitrite. Chem. Sci., 2015, 6, 2963-2967 (IF: 9.14);

Sun, X.; Xu, Q.; Kim, G.; Flower, S. E.; Lowe, J. P.; Yoon, J.; Fossey, J. S.; Qian, X. H.; Bull, S.; James, T. D., A water-soluble boronate-based fluorescence probe for the selective detection of peroxynitrite and imaging in living cells. Chem. Sci. 2014. 5, 3368-3373 (Front cover, IF: 9.14);

Sun, X., S.-Y. Xu, S. E. Flower, J. S. Fossey, X. Qian and T. D. James, "Integrated" and "insulated" boronate-based fluorescent probes for the detection of hydrogen peroxide. Chem. Commun., 2013, 49, 8311-8313 (Front cover, reported in various scientific media, UK, top 10 paper assessed by Chem.Commun. IF: 6.57);

Sedgwick, A. C.; Sun, X.; Kim, G.; Yoon, J.; Bull, S.; James, T. D. Chem. Commun. 2016, DOI: 10.1039/C6CC06829D (IF: 6.57);

Sun X., Lacina K., Ramsamy E., Xu S., Qiang T. T., Bull S., Marken F., and James T. D., Reaction-based Indicator displacement Assay (RIA) for the colorimetric and fluorometric detection of hydrogen peroxide. Org. Chem. Front., 2016, In Peer Review (IF: 4.693);

James, T. D.; Dull, S.; Sun X, “Method of detecting peroxynitrite using a complex of a saccharide and an arylboronate-based fluorescent probe”, PCT Patent No: WO 2015128622;

 

3. Saccharide sensing based on interaction between boronic acid and diol.

·         

      Sun X., James T. D.,* Anslyn E. V.* Arresting “Loose Bolt” Internal Conversion from −B(OH)2 Groups is the Mechanism for Emission Turn-On in ortho-Aminomethylphenylboronic Acid-Based Saccharide Sensors. J. Am. Chem. Soc., 2018, 140, 2348–2354 (IF: 14.357) (Highlighted in Spotlights on Recent JACS Publications);

 

Sun, X.; James, T. D., Glucose Sensing in Supramolecular Chemistry. Chem. Rev. 2015, 115, 8001-8037 (IF: 46.57);

Sun X., Zhai W., Fossey J. S. and James T. D. Boronic acid for fluorescence imaging of carbohydrate. Chem. Commun. feature article. 2016, 52, 3456-3469 (Front cover, IF: 6.57);

Sun X., Anslyn E. V. Investigation of Boronic Acid Binding Affinity with Monosaccharide-mimicked Diols Based on Indicator Displacement Assay. in preparation;

Sun X., Kim G., Xu Y., Yoon J. and James T. D., A water-soluble copper (II) complex for the selective fluorescence detection of nitric oxide/nitroxyl and imaging in living cells. ChemPlusChem, 2015, 1, 30-34 (IF: 3.00);

Sun, X., Y. F. Xu, W. P. Zhu, C. S. He, L. Xu, Y. J. Yang and X. H. Qian, Copper-promoted probe for nitric oxide based on o-phenylenediamine: Large blue-shift in absorption and fluorescence enhancement. Anal. Methods, 2012, 4, 919-922. (The top 25 most read articles of 2012 in Analytical Methods, IF: 1.92)

      4. Combination of small molecular fluorescent probe with functional materials.

 Sun, X.; Zhu, B.; Ji, D.-K.; Chen, Q.; He, X.-P.; Chen, G. R.; James, T. D., Selective Fluorescence Detection of Monosaccharides Using a Material Composite Formed Between Graphene Oxide and Boronate-based Receptors. ACS Appl. Mater. Interfaces. 2014, 6, 10078–10082 (IF: 7.15);

X. H. Qian, W. P. Zhu, C. S. He, Y. F. Xu, X. Sun, L. Ren. "Material and method used for separating heavy metals from traditional Chinese medicine extract and food", Patent No: CN 102806070.

Guo, S.; Chen, J.; Cai, B.-Y.; Chen, W. W.; Li, Y.-F.; Sun, X.; Chen, G. R.; He, X.-P.; James, T. D., Low-dimensional materials facilitate the conjugation between fluorogenic boronic acids and saccharides. Mater. Chem. Front. 2016, Minor Revision.  

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