研究方向

目前研究方向:

1、超声造影剂及超声造影成像;

2、超声控制基因/药物递送

3、多模造影剂的设计、制备及其诊疗应用

 

进一步扩展方向

4、超声功能成像与分子成像

 

科研项目

1.     国家重大科研仪器研制项目 (81827801) 超声脑小血管超分辨及动态多参量成像系统,2019.01-2023.12796.72万元,在研,主要参加

2.     国家自然科学基金面上项目(31771075),超声/磁场对双峰分布相变纳米液滴的协同操控及其在肿瘤诊疗中的应用,2018.01-2021.1258万元,在研,主持

3.     国家重点研发计划课题(2016YFC0100702经颅血脑屏障开放/溶栓三维微泡与空化超声成像及诊疗系统,2016.07-2018.12, 80万元,在研,主持

4.     国家自然科学基金面上项目(31470909),基于可控空化内皮损伤的动脉粥样硬化斑块动物模型及其活体评价,2015.01-2018.1285万元,在研,主持。

5.     国家自然科学基金面上项目(31271003),基于血管内膜超声微泡空蚀的局部可控易损斑块动物模型建立及活体评价方法,2013.01-2013.1215万元,已结题,主持。

6.     国家973项目课题(2010CB732603),易损斑块无创、高分辨超声功能与分子定量成像,2010.01-2014.08396万元,已结题,主要参加。

7.     国家自然科学基金面上项目(10704060),深部稀疏微小血管及管内单泡超宽带超声灌注成像,2008.01-2010.1225万元,已结题,主持。

科研奖励

1、获 2016年度陕西省科学技术奖一等奖

2、参与完成的研究成果入选“2017年中国医学十大进展”

科研成果

 BOOKS

1. Mingxi Wan, Yujin Zong, Supin Wang, Biomedical Ultrasound, Science Press, Beijing, 2010
2. Mingxi Wan, Yujin Zong, Supin Wang, Mingzhu Lu, Experiments in Biomedical Ultrasound, XI'AN Jiaotong University Press, Xi'an, 2010
3. Yujin Zong, Shanshan Xu, Tom Matula, Mingxi Wan, Chapter 5. Cavitation-enhanced mechanical effects and applications, in book: Cavitation in Biomedicine, Principles and Techniques, Editor: M.Wan, Y. Feng, Gail ter Haar, Springer, 2015
 
REFERRED JOURNAL ARTICLES:                                   
1.   Shanshan Xu, Nan Chang, Rui Wang, Xiaodong Liu, Shifang Guo, Wupin Wang, Yujin Zong*, Mingxi Wan*,Acoustic droplet vaporization and inertial cavitation thresholds andefficiencies of nanodroplets emulsions inside the focused region using adual-frequency ring focused ultrasound, Ultrasonics Sonochemistry, 2018, 48: 532-537
2.   Chen Bai, Meiling Ji, Xinyu Zhang, Yujin Zong*, Mingxi Wan*, Design and Characterization of an Acoustically and Structurally Matched 3-D-Printed Model for Transcranial Ultrasound Imaging, IEEE Trans on UFFC, 2018, 65(5):
3.   Shukuan Lu, Hong Hu, Xianbo Yu, Jiangying Long, Bowen Jing, Yujin Zong*, Mingxi Wan*, Passive acoustic mapping of cavitation using eigenspace-based robust Capon beamformer in ultrasound therapy, Ultrasonics Sonochemistry, 2018, 41: 670-679
4.   Diya Wang, Mengnan Xiao, Hong Hu, Yu Zhang, Zhe Su, Shanshan Xu, Yujin Zong, Mingxi Wan, DCEUS-based focal parametric perfusion imaging of microvessel with single-pixel resolution and high contrast, Ultrasonics, 2018, 84: 392-403
5.   Shifang Guo, Aiwei Shi, Shanshan Xu, Xuan Du, Xin Wang, Yujin Zong, Ayache Bouakaz, and Mingxi Wan, Lowering of acoustic droplet vaporization threshold via aggregation, Appl. Phys. Lett., 2017, 111: 254102
6.   Diya Wang, Yujin Zong, Xuan Yang, Hong Hu, Jinjin Wan, Lei Zhang, Ayache Bouakaz, Mingxi Wan, Ultrasound Contrast Plane Wave Imaging Based on Bubble Wavelet Transform: in vitro and in vivo Validations, Ultrasound in Medicine & Biology, 2016,  42(7): 1584-1597
7.   J. Hu#, Y. Zong#, J. Li, X. Zhou, J. Zhang, T. Zhu, M. Jiao, H. Su*, B. Bo, InVitro and In Vivo Evaluation of Targeted Sunitinib-Loaded Polymer Microbubbles against Proliferation of Renal Cell Carcinoma, Journal of Ultrasound in Medicine, 2016, 35: 589-597.
8.    A. Shi, P. Huang, S. Guo, L. Zhao, J. Jia, Y. Zong*, M. Wan*, Precise spatial control of cavitation erosion in a vessel phantom by using an ultrasonic standing wave, Ultrasonics Sonochemistry, 2016, 31: 163-172.
9.   J. Tan, B. Pham, Y. Zong, C. Perez, D. Maris, A. Hemphill, C. Miao, T. Matula, P. Mourad, H. Wei, D. Sellers, P. Horner*, S. Pun*, Microbubbles and Ultrasound Increase Intraventricular Polyplex Gene Transfer to the Brain, Journal of Controlled Release, 2016, 231:86-93.
10.    Yangzi Qiao, Yujin Zong, Hui Yin, Nan Chang, Zhaopeng Li and Mingxi Wan, Spatial and temporal observation of phase-shift nano-emulsions assisted cavitation and ablation during focused ultrasound exposure, Ultrasonics Sonochemistry,2014, 21(5): 1745-1751
11.    Shanshan Xu, Yujin Zong, Wusong Li, Siyuan Zhang and Mingxi Wan, Estimation of bubble size distribution in acoustic droplet vaporization, Ultrasonics Sonochemistry, 2014, 21(3): 975-983
12.    Xiaolin Gu, Min Wei, Yujin Zong, Hujie Jiang, Mingxi Wan, Flow Quantification with Nakagami Parametric Imaging for Suppressing Contrast Microbubbles Attenuation, Ultrasound in Medicine & Biology, 2013, 39(4): 660–669
13.    Siyuan Zhang, Yujin Zong, Mingxi Wan, Xiaojun Yu, Quanyou Fu, Ting Ding, Fanyu Zhou, and Supin Wang, Compare ultrasound-mediated heating and cavitation between flowing polymer- and lipid-shelled microbubbles during focused ultrasound exposures, J. Acoust. Soc. Am. 2012, 131 (6): 4845-4855
14.    Yiyang Wan, Siyuan Zhang, Yujin Zong and Mingxi Wan, Formation of two-way Lamb waves and force potential wells using single conventional ultrasonic transducer, Proceedings of Meetings on Acoustics, 2012, Vol. 15, 045003
15.   Zhong Hui, Ding Guanhua, She Yanmin, Y. Zong, M. Wan*, “The study of sub-harmoniccavitation maging based on pulse inversion technique for the monitoring of high intensity focused ultrasound therapies,” Journal of Medical Imaging and Health Informatics, vol. 4, pp. 410-415, 2014.
16.    Zong Yujin, Wan Mingxi, The Study of Sub-Harmonic Cavitation Imaging Based on Pulse Inversion Technique for the Monitoring of High Intensity Focused Ultrasound Therapies, Journal of medical imaging and health informatics, 2014, 4(3): 410-415
17. Haili Su, Yongfeng Du, Yunqiu Qian, Yujin Zong, Jun Li, Ran Zhuang, Jianguo He, Zhangrui Wei, Jun Zhang, Xiaodong Zhou, Targeted Ultrasound Contrast Imaging of Matrix Metalloproteinase-2 in Ischemia–Reperfusion Rat Model: Ex Vivo and In Vivo Studies, Molecular Imaging and Biology, 2011, 13(2): 293-302
18.    Zong YJ, Wan MX, Wang SP, Zhang GL. Optimal design and experimental investigation of surfactant encapsulated microbubbles. Ultrasonics. 2006, 44(S1): e119-e122.
19.    Zong YJ, Li B, Wan MX. Detection of individual microbubbles using wavelet transform based on a theoretical bubble oscillation model. Lecture Notes in Computer Science. 2006, 4222: 354-363.
20.    Zong YJ, Wan MX, Wang SP, Chen H, Zhang G. Optimal design and experimental measurement of the subharmonic characterizations of encapsulate microbubble. Chinese Journal of Acoustics. 2006, 25(1): 45-57.
 
CONFERENCES:
1.     Y. Zong, R. Wang, X. Zou, L. Zhang, G. Liu, and M. Wan*, “Local cavitation induced vessel wall injury of artery and its potential application in animal model of atherosclerosis,” IEEE International Ultrasonics Symposium, Taipei, Oct. 21-24, 2015.
2.     Y. Zong, X. Zou, R. Wang, Y. Feng, M. Wan*, Ultrasound-enhanced extravasation of multifunctional nanodroplets from leaky vessel, IEEE Ultrasonics Symposium (IUS), IEEE International Ultrasonics Symposium, Taipei, Oct. 21-24, 2015
3.     Y.J. Zong, J.J. Wan, MX. Wan. (2014) Non-invasive assessment of mechanical and hemodynamic parameters of carotid artery and plaque, International conference on biomedical ultrasound, (Shenzhen)
4.     YJ. Zong, N. Zheng, SS Xu, MX. Wan. (2013) Low intensity focused ultrasound triggered local drug delivery from liposome-loaded microbubbles, International Society for Therapeutic Ultrasound Symposium (Shanghai)
5.     Mingxi Wan, Yujin Zong, (2012) Noninvasive Ultrasound Elastography and Contrast-Enhanced Parametric Imaging of Carotid Plaque, IEEE-EMBS International Conference on Biomedical and Health Informatics (Shenzhen)
6.     Y.J. Zong, J.J. Wan, Y.Z. Qiao, W.S. Li, X.R. Zou and M.X. Wan. (2013) Cavitation endothelium damage of large artery vessel: a potential application to animal model of atherosclerosis, International Conference on Health Informatics (Vilamoura)
7.   Jinjin Wan, Yujin Zong, Mimi Hu and Mingxi Wan, (2013)Noninvasive Strain Imaging and Hemodynamic Evaluation of Atherosclerosis, International Conference on Health Informatics (Vilamoura)
 
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