代表性研究成果

 

1)单个活细胞表面电荷的光电化学成像与可视化监测。对传统光寻址电位传感成像技术进行改进,基于半导体-电解液界面发展了新型光电化学成像系统,最终实现了单个活细胞光电化学成像,可检测单细胞-基底接触面的电荷分布,适用于成骨细胞,小鼠神经细胞,人间充质干细胞等多种细胞类型,可实时成像监测间充质干细胞的膜表面动态过程。在光学成像方法之外基于细胞表面电学信息提供了一种新型的无标记光电化学成像方法。(Anal. Chem., 2017898129-8133 Anal. Chem., 2018, 90, 14, 8708-8715 Anal. Chem., 2019, 91, 5896-5903

 

 

 

2)自组装单层纳米碳点用于光电化学成像。研究发现碳点具有半导体光电效应,可在光照下产生光电流,对其光电效应机理进行了研究,并将自组装单层纳米碳点应用于光电化学成像,在生物成像中具有良好的应用前景,有希望用于机器人仿生皮肤与模拟触觉。 (Mater. Horiz., 2018, 5 (3), 423-428back cover paper)

 

 

 

 

 

 

科研项目

 

1    西安交通大学基本科研业务费,xzy01201907120191- 202112月,在研,主持。

2    西安交通大学青年拔尖人才支持计划项目,YX6J00320189- 20249月,在研,主持。

3    欧盟玛丽-斯克沃多夫斯卡居里行动项目,H2020-MSCA-IF-2014-660489,项目来源:欧盟委员会(Commission of the European)20157- 20177月,结题,主持。

 

发表论文

    1) Jian Wang, Zhao Yang, Wei Chen, Liping Du, Bo Jiao, Steffi Krause, Ping Wang, Qiuping Wei, De-Wen Zhang*, Chunsheng Wu*. Modulated light-activated electrochemistry at silicon functionalized with metal-organic frameworks towards addressable DNA chips. Biosensors and Bioelectronics 2019, 146: 111750. (IF = 9.518)

    2) Jian Wang, Shu Kong, Fangming Chen, Wei Chen, Liping Du, Wen Cai, Liquan Huang, Chunsheng Wu*, De-Wen Zhang*. A bioelectronic taste sensor based on bioengineered Escherichia coli cells combined with ITO-constructed electrochemical sensors. Analytica Chimica Acta 2019, 1079: 73-78. (IF = 5.256)

3) Fan Wu, Bo Zhou, Jian Wang, Muchun Zhong, Anirban Das, Michael Watkinson, Karin Hing, De-Wen Zhang*, Steffi Krause*. Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges. Analytical Chemistry 2019, 91(9): 5896-5903. (IF = 6.350)

4) Ying Tu, Norlaily Ahmad, Joe Briscoe, De-Wen Zhang*, Steffi Krause*, Light-Addressable Potentiometric Sensors Using ZnO Nanorods as the Sensor Substrate for Bioanalytical Applications. Analytical Chemistry, 2018, 90, 8708-8715. (IF = 6.350)

5) De-Wen Zhang, Nikolaos Papaioannou, Naomi Michelle David, Hui Luo, Hui Gao, Liviu Cristian Tanase, Thibault Degousée, Paolo Samorì, Andrei Sapelkin, Oliver Fenwick, Maria-Magdalena Titirici*, Steffi Krause*, Photoelectrochemical Response of Carbon Dots (Cds) Derived from Chitosan and Their Use in Electrochemical Imaging. Materials Horizons 2018, 5, 423-428. (IF = 14.356)

     6) De-Wen Zhang, Fan Wu, Steffi Krause*, LAPS and SPIM Imaging Using Ito-Coated Glass as the Substrate Material. Analytical Chemistry, 2017, 89, 8129-8133. (IF = 6.350)

      7)  Fan Wu, Inmaculada Campos, De-Wen Zhang*, Steffi Krause*, Biological Imaging Using Light-Addressable Potentiometric Sensors and Scanning Photo-Induced Impedance Microscopy. Proceedings of the Royal Society. A, Mathematical, physical, and engineering sciences, 2017, 473, 20170130. (IF = 2.818)

      8) De-Wen Zhang, Fan Wu, Jian Wang, Michael Watkinson, Steffi Krause*, Image Detection of Yeast Saccharomyces Cerevisiae by Light-Addressable Potentiometric Sensors (LAPS). Electrochemistry Communications, 2016, 72, 41-45. (IF = 4.197)

      9) Ting Cao, Ji Nie, Liang-Yuan Cai, Xiao-Hui Zhang, De-Wen Zhang*, Ying-Lin Zhou*, Xin-Xiang Zhang*, A Cupric Ion Triggered DNA Diode Based on a Tandem Linkage-Cleavage Reaction. Chemical Communications, 2016, 52, 12490-12493. (IF = 6.164)

     10) De-Wen Zhang, Ji Nie, Fang-Ting Zhang, Li Xu, Ying-Lin Zhou*, Xin-Xiang Zhang*, Novel Homogeneous Label-Free Electrochemical Aptasensor Based on Functional DNA Hairpin for Target Detection. Analytical Chemistry, 2013, 85, 9378-9382. (IF = 6.350)

     11) De-Wen Zhang, Jing-Xin Liu, Ji Nie, Ying-Lin Zhou*, Xin-Xiang Zhang*, Micropipet Tip-Based Miniaturized Electrochemical Device Combined with Ultramicroelectrode and Its Application in Immobilization-Free Enzyme Biosensor. Analytical Chemistry, 2013, 85, 2032-2036. (IF = 6.350)

     12) De-Wen Zhang, Cui-Jin Sun, Fang-Ting Zhang, Li Xu, Ying-Lin Zhou*, Xin-Xiang Zhang*, An Electrochemical Aptasensor Based on Enzyme Linked Aptamer Assay. Biosensors and Bioelectronics, 2012, 31, 363-368. (IF = 9.518)

     13) De-Wen Zhang, Fang-Ting Zhang, Yi-Ran Cui, Qin-Pei Deng, Steffi Krause, Ying-Lin Zhou*, Xin-Xiang Zhang*, A Label-Free Aptasensor for the Sensitive and Specific Detection of Cocaine Using Supramolecular Aptamer Fragments/Target Complex by Electrochemical Impedance Spectroscopy. Talanta, 2012, 92, 65-71. (IF = 4.916)